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ItalianoPRGF Endoret in Cluj-Napoca: healing with plasma from your own blood
We use PRGF Endoret for extractions, implants, sinus lifts and in the treatment of periodontitis, when your dentist considers that your healing needs extra support. It all starts with a few millilitres of your own blood.
Book a consultation- Fraction 1plasma with platelets at the same level as in your blood; the fibrin membrane is made from it
- Fraction 2plasma rich in growth factors, about twice as concentrated; it becomes the liquid and the clot applied to the socket or the implant
- White blood cellsnot used in PRGF
- Red blood cellsstay in the tube
The short answer
PRGF Endoret (Plasma Rich in Growth Factors) is a technique developed by BTI Biotechnology Institute in Spain, in which a small amount of your blood is centrifuged to obtain plasma with a higher concentration of platelets and growth factors. The plasma is applied at the treatment site, for example after an extraction or when an implant is placed. Clinical studies show less pain and inflammation in the first few days and better healing of the gums. At Dental Chic Cluj-Napoca, your dentist will tell you at the consultation whether PRGF is indicated in your case.
What PRGF Endoret is
Your blood contains platelets, and platelets contain proteins that signal to tissues that they need to repair themselves: growth factors. When you cut your finger, they are the first to reach the wound. PRGF Endoret concentrates exactly this part of your blood and places it where you need it.
The system was developed by BTI Biotechnology Institute in Vitoria, Spain, under the scientific coordination of Dr. Eduardo Anitua. Because the plasma comes from your own blood, there is no risk of a rejection reaction and no risk of a disease being passed on from a donor.
PRGF is prepared in three forms, each with its own role:
Liquid
The dentist uses it to moisten the surface of the implant or the bone graft material before placement.
Clot
It fills the socket left after an extraction or is mixed with the bone graft.
Fibrin membrane
Elastic, it covers the area and protects the gum while it heals.
What problems PRGF can help you with
PRGF does not replace surgical technique, oral hygiene or bone grafting. It is an adjunct: it helps your tissues do better what they already do on their own. Here are the situations in which we recommend it most often, and what the studies say about each one.
Pain and swelling after an extraction
day 3less pain with PRGF in a 2026 randomised study
The first three days after an extraction are usually the most uncomfortable. In a randomised clinical trial published in 2026 (Anitua et al., 46 patients), the group treated with PRGF reported less pain on the third day, and tissue analysis showed 48.7% new bone in the sockets, compared with 36.1% in the group without PRGF. A review of 8 studies (Del Fabbro, 2019, 614 teeth) consistently found less pain and inflammation, with the caveat that the size of the benefit cannot yet be established precisely.
More details
If you need a tooth removed, including a wisdom tooth, you can discuss with your dentist at the consultation whether PRGF makes sense in your case. You will find details about the procedure on our page about oral surgery in Cluj-Napoca.
Dry socket after wisdom tooth extraction
40 extractionsdouble-blind study: fewer cases of dry socket with PRGF
Dry socket (alveolar osteitis) happens when the blood clot in the place of the removed tooth is lost or does not form properly. The typical sign is pain that returns or gets worse 2-4 days after the extraction, sometimes with an unpleasant smell. It is more common after the removal of lower wisdom teeth, in smokers and in people who have had dry socket before.
More details
A PRGF clot placed in the socket provides stable support for healing. In a double-blind study of 40 wisdom tooth extractions (Haraji, 2012), the side treated with PRGF had significantly fewer cases of dry socket and less pain than the untreated side, in the same patient.
Bone loss after extraction and preparing for an implant
96.7% vs 45.5%sockets at least 75% regenerated, with and without PRGF
Once a tooth is removed, the bone in that area starts to shrink, in width and in height. If you are planning an implant, the bone that remains matters. In a 2015 randomised clinical trial (Anitua et al., 60 patients), 96.7% of the sockets treated with PRGF regenerated by at least 75%, compared with 45.5% in the control group, and bone density was higher. The 2026 study measured horizontal ridge loss that was about 1.1 mm smaller.
More details
To be fair: both studies were carried out by the team that developed the system, and other research has not found differences this large. That is why your dentist recommends PRGF based on your specific situation, not automatically.
Dental implants, bone grafting and sinus lift
the first daysless pain, swelling and bruising after sinus lift
When a dental implant is placed, liquid PRGF is applied to the surface of the implant, and the clot or membrane can protect the area. When bone grafting or a sinus lift is needed, the plasma is mixed with the graft material, which makes it easier to shape and hold in place.
More details
What we know from the studies: for sinus lifts, a randomised study (Del Fabbro, 2015) reported less pain, swelling and bruising in the first few days. As for bone formation, the research results are still mixed (Dragonas, 2019), so we will not tell you that PRGF makes your implant last longer. We will tell you that it can make your recovery more comfortable.
PRGF can also be used in full-arch rehabilitations on implants, such as fixed teeth on implants, All-on-4 and All-on-6, where several areas are treated in the same session. You can see treatments like these in our patients' clinical cases.
Periodontitis and bone defects around the teeth
6 monthsshallower pockets in a 2020 clinical study
In advanced periodontitis, the disease destroys the bone around the teeth and forms pockets between the gum and the tooth. In surgical treatment, after the pockets are cleaned, PRGF can be applied to the bone defects. A clinical study (Panda, 2020) showed shallower pockets and better gum attachment at 6 months when PRGF was added to subgingival cleaning. Other studies have not found an added benefit compared with conventional regeneration techniques. You can read about the full treatment on our page about periodontitis treatment.
Patients with diabetes, on anticoagulants or on bisphosphonates
3 situationsdiabetes, anticoagulants and bisphosphonate treatment, studied separately
Some conditions make healing slower or riskier. This is where PRGF is discussed most often:
More details
- Diabetes: in 34 patients with insulin-dependent diabetes, the side treated with PRGF healed better between days 3 and 14 after the extraction (Mozzati, 2014).
- Anticoagulants or bleeding disorders: in 120 patients, PRGF controlled bleeding after extraction as effectively as the fibrin glue commonly used (Cocero, 2015).
- Bisphosphonates (osteoporosis treatment): these patients have a risk of jaw bone necrosis after procedures. PRGF protocols have been studied in hundreds of patients, with encouraging results, but without comparative studies (Mozzati, 2015).
If any of these apply to you, tell your dentist at the first consultation which medicines you take. The plan for your procedure starts from there.
It's for you if…
You need a wisdom tooth removed and you have read about dry socket or have had it before.
You are about to have an implant and want your recovery to be as comfortable as possible.
You need a sinus lift or bone grafting before an implant.
You have diabetes, take anticoagulants or have been treated for osteoporosis and you are worried about healing.
You smoke and know that healing after an extraction takes longer for you.
You are being treated for periodontitis and your dentist has suggested gum surgery.
How it works
- The consultation and the planYour dentist assesses the area, your X-ray and your medical history and tells you whether PRGF is indicated. You receive the plan and the costs in writing.
- The blood drawa few minutesOn the day of the procedure, the nurse draws 4 small tubes, as for a routine blood test.
- Centrifugationabout 8 minutesThe tubes are centrifuged in the clinic. The dentist separates the platelet-rich plasma fraction and activates it with calcium chloride, obtaining the liquid, the clot or the membrane.
- Application during the procedureThe plasma is applied to the socket, the implant, the bone graft or the periodontal defect. Preparation happens in parallel with the procedure, so it does not significantly extend the time you spend in the chair.
- Recovery and follow-upYou receive written instructions for home care and a follow-up appointment.
What the studies say, in brief
Extraction
Less pain and inflammation in the first few days, better gum healing
Randomised studies and systematic reviews, with favourable but variable results
Dry socket after wisdom tooth removal
Fewer cases of dry socket
Double-blind study of 40 extractions
Bone in the socket
More new bone and less ridge loss
Randomised studies, carried out by the team that developed the system
Sinus lift and bone grafting
More comfortable recovery in the first few days
The effect on bone is still mixed
Periodontitis
Shallower pockets in some studies
Results differ between studies
At-risk patients
Better healing in diabetics, bleeding control as effective as conventional methods
Small studies or studies without a control group
We chose to show you the limits as well, not just the good results. PRGF is a useful tool within a well-designed treatment plan, not a solution that works on its own.
PRGF, PRP and PRF: what's the difference
All three start from the patient's own blood, but they are prepared differently and give different products:
PRP
Platelet-rich plasma: the older method, with two centrifugation steps and less controlled activation.
PRF and A-PRF
Platelet-rich fibrin: obtained without an anticoagulant, and the clot also contains white blood cells.
PRGF Endoret
A single short centrifugation, plasma without white blood cells, activated in a controlled way with calcium chloride. A laboratory study (Baca-Gonzalez, 2022) showed that PRGF releases growth factors more slowly and contains very few inflammatory proteins.
Your dentist chooses the right technique for your procedure and explains why.
Who performs your procedure
The surgical procedures in which we use PRGF, from wisdom tooth extractions to bone grafting and sinus lifts, are carried out by our dento-alveolar surgery dentists. Dr. Veronica Constantinov is a specialist in dento-alveolar surgery, with competence in implantology, and lectures at professional congresses.
How much PRGF costs at Dental Chic Cluj-Napoca
The PRGF technique is added to the procedure it is used for, such as an extraction, an implant or a sinus lift. Its price is in the clinic's price list, in the implantology section, and after the consultation you receive your treatment plan in writing, with the exact total.
When PRGF is not recommended
PRGF is not suitable for everyone. Your dentist will postpone it or choose another solution if you have:
- a very low platelet count or a condition that affects platelet function;
- an active infection in the area to be treated, until it has cleared;
- significant anaemia or an active blood disorder;
- a fever or an unstable general condition on the day of the procedure.
A few things to know beforehand: anti-inflammatory medicines such as ibuprofen, taken within 48 hours before the procedure, can reduce platelet activity, and smoking reduces the effect. Tell your dentist which medicines you take, including over-the-counter ones.
Frequently asked questions
What is PRGF Endoret?
PRGF Endoret is a technique in which a small amount of your blood is centrifuged to obtain plasma rich in platelets and growth factors. The plasma is applied at the treatment site to support tissue healing. The system was developed by BTI Biotechnology Institute in Spain.
Does the blood draw hurt?
The blood draw is the same as for a routine blood test: a small prick in the arm and 4 small tubes. It takes a few minutes.
How much blood is taken?
Usually 4 tubes, about 20-36 ml, depending on the procedure. That is much less than a blood donation.
Is PRGF safe?
The plasma comes from your own blood, so there is no risk of a rejection reaction and no risk of a disease being passed on from a donor. The only discomfort is the blood draw itself. Your dentist checks beforehand whether you have a condition for which PRGF is not indicated.
Does PRGF help healing after wisdom tooth extraction?
Studies show less pain and inflammation in the first few days and fewer cases of dry socket when PRGF is placed in the socket. The benefit varies from one patient to another, and your dentist will tell you at the consultation whether they recommend it in your case.
Can I prevent dry socket with PRGF?
In studies, PRGF reduces the risk of dry socket, but it does not eliminate it. Following the aftercare instructions matters just as much: no smoking, no vigorous rinsing and no drinking through a straw in the first few days.
Does PRGF make an implant last longer?
There is no evidence that PRGF increases implant success rates in humans. What the studies show is a more comfortable recovery and better tissue healing in the first few days.
What is the difference between PRGF and PRF?
PRF is obtained without an anticoagulant and contains white blood cells, while PRGF uses a single centrifugation, contains no white blood cells and is activated in a controlled way. Both start from the patient's own blood. Your dentist chooses the technique based on the procedure.
How much does PRGF cost in Cluj-Napoca?
At Dental Chic Cluj-Napoca, the price of the PRGF technique is published in the clinic's price list and is added to the cost of the procedure. You receive the exact total in writing, in your treatment plan.
Can I have PRGF if I have diabetes or take anticoagulants?
Yes, and PRGF has been studied specifically in these patients: in diabetics, healing after extraction was better, and in patients with bleeding disorders, the plasma controlled bleeding as well as conventional methods. Tell your dentist which treatment you are on, so the plan can take it into account.
References
- Anitua E. et al., Clinical Oral Investigations, 2015. doi.org/10.1007/s00784-014-1278-2
- Anitua E. et al., Clinical Oral Investigations, 2026. doi.org/10.1007/s00784-026-06769-z
- Del Fabbro M., Panda S., Taschieri S., Journal of Evidence-Based Dental Practice, 2019. doi.org/10.1016/j.jebdp.2018.11.003
- Haraji A. et al., National Journal of Maxillofacial Surgery, 2012. doi.org/10.4103/0975-5950.102150
- Mozzati M. et al., Journal of Oral and Maxillofacial Surgery, 2014. doi.org/10.1016/j.joms.2013.10.010
- Cocero N. et al., Blood Transfusion, 2015. doi.org/10.2450/2014.0124-14
- Mozzati M. et al., Journal of Craniofacial Surgery, 2015. doi.org/10.1097/scs.0000000000001535
- Del Fabbro M. et al., Clinical Implant Dentistry and Related Research, 2015. doi.org/10.1111/cid.12171
- Dragonas P. et al., Journal of Cranio-Maxillofacial Surgery, 2019. doi.org/10.1016/j.jcms.2019.01.012
- Panda S. et al., Brazilian Oral Research, 2020. doi.org/10.1590/1807-3107bor-2020.vol34.0034
- Baca-Gonzalez L. et al., International Journal of Implant Dentistry, 2022. doi.org/10.1186/s40729-022-00440-4
Talk to a dentist about your procedure
At the consultation you will find out whether PRGF makes sense in your case, what the alternatives are and how much the whole plan costs, in writing. We speak Romanian, English, French, Italian and German.
Book a consultation